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13 thoughts on “Ubiquinol, designated as an orphan drug for treatment of primary coenzyme Q10 deficiency

    • admin Post author

      Statin drugs block our cells’ ability to make many essential compounds, including cholesterol and CoQ10, thereby decreasing the levels of both.
      Hope this helps,
      Peter Langsjoen, MD

  • Ed Nichol

    Do you test Q levels only in blood or are there comparisons between tissue and blood. I think that the muscles might demand fuel in the form of fat. This demand on fat and limited fat soluble nutrient(s) would create a deficiency in non-muscle cells. We could call the effect “ageing”. ie’ very strong workers with white hair, extreme athletes getting cancer,

  • Louise Nagle

    My husband was recently told that COQ10 relieves severe hand cramping due to arthritis. I was not able to find this out in the several pages I found. Figuring one of them got their story off I thought it best to get that answer from you.

  • perla

    Are there any studies that show that we can take lower doses of Ubiquinol vs usual doses of ubiquinone and still have the same efficacy?

    • admin Post author

      The designation of ubiquinol for the deficiency disease is made only in base of the response of patients suffering this disease. Clinician are supplementing with an average of 30mg/kg/day to see some recovery depending on the severity of the patho phenotype. In animal models of the disease we are treating them with 50% ubiquinol of previous ubiquinone treatments to get similar improvement.

      Hope this answer to you.

  • Katherine Gibson

    Hello, I was wondering where to buy the same CO-Q-10 that Mr. Frederick L. Carne came out with. Do you know where I can buy it. Thank you so much for your help, any information would be helpful.

  • Ed Nichol

    Dr Peter,
    I understand that you are busy. Could you direct me to the literature pertaining to how the body produces Ubiquinol or converts lower level quinones. I am a convert and the only problem that I have is convincing people to try Ubiquinol. I am sure it is the missing nutrient in the ageing process. This week again a convert took ten days from cane and much pain to simply no cane and no pain. Possibly it is an example of the diffusion of sufficient ubiquinol to repair damaged nerves. I have a list of obvious reverse ageing on a growing list of people. Along with the literature describing the importance of the Q Cycle I have added my own theory that muscle activity can demand fat for fuel and the associated fat soluble nutrients. This fat for fuel scavenging creates serious deficiencies in non-muscle cells that we observe as ‘ageing’. A second request to you is whether anyone tests Q levels in various parts of the body to see if nutrient scavenging is taking place.
    Thank you
    Ed Nichol