ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency

Luis Vázquez-Fonseca 1,2,†, Jochen Schaefer 3,†, Ignacio Navas-Enamorado 1,4,5,
Carlos Santos-Ocaña 1,6, Juan D. Hernández-Camacho 1,6, Ignacio Guerra 1, María V. Cascajo 1,6, Ana Sánchez-Cuesta 1,6, Zoltan Horvath 3,‡, Emilio Siendones 1, Cristina Jou 6,7, Mercedes Casado 6,7, Purificación Gutiérrez 1, Gloria Brea-Calvo 1,6, Guillermo López-Lluch 1,6,
Daniel J. M. Fernández-Ayala 1,6, Ana B. Cortés-Rodríguez 1,6, Juan C. Rodríguez-Aguilera 1,6, Cristiane Matté 8, Antonia Ribes 6,9, Sandra Y. Prieto-Soler 10, Eduardo Dominguez-del-Toro 10, Andrea di Francesco 5, Miguel A. Aon 5, Michel Bernier 5, Leonardo Salviati 2, Rafael Artuch 6,7, Rafael de Cabo 5, Sandra Jackson 3 and Plácido Navas 1,6,*

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Call for papers in Special Issues of CoQ10

1. A special issue on CoQ10 in health has been opened in Antioxidants. All authors that submit a paper will have a 15% discount as regular ICQA members. Expected publication in 2021. To update your membership please contact Monica Glebocki at mglebocki@icquaproject.org

Deadline for manuscript submissions: 31 December 2020.

Detailed information can be find at the link:

https://www.mdpi.com/journal/antioxidants/special_issues/CoQ10_health

2. A special issue has been approved in Free Radical in Biology & Medicine edited by Alberto Sanz and Plácido Navas that appears in the journal web. Topic: Mitochondrial Coenzyme Q Homeostasis: signaling, respiratory chain stability and diseases. Expected publication in 2021.

Submission deadline: 15 November 2020

Detailed information can be find at the link:

https://www.journals.elsevier.com/free-radical-biology-and-medicine/forthcoming-special-issues

Open job offer

Dr. Catarina Quinzii is looking to hire a postdoctoral researcher to work in her lab.  The research project offered are below:

POSTDOCTORAL POSITION AVAILABLE

For further details please contact 

To apply please send a CV including a statement of research interests and names of 2 references to: Catarina M Quinzii (cmq2101@columbia.edu), by February 29, 2020. Selected applicants will be invited to an interview in person or via Skype. Candidates will be informed about the selection by March 2020 with a projected June 2020 start date. The selected candidate must submit the necessary documents to Columbia University. Foreign applicants are encouraged to apply early to ensure adequate time to obtain visas

Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview 3

Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview

Abstract: Longevity is determined by a number of factors, including genetic, environmental and lifestyle factors. A major factor affecting longevity is the development of degenerative disorders such as cardiovascular disease, diabetes, kidney disease and liver disease, particularly where these occur as co-morbidities. In this article, we review the potential role of supplementation with coenzyme Q10 (CoQ10) for the prevention or management of these disorders. Thus, randomised controlled clinical trials have shown supplementation with CoQ10 or CoQ10 plus selenium reduces mortality by approximately 50% in patients with cardiovascular disease, or in the normal elderly population, respectively. Similarly, CoQ10 supplementation improves glycaemic control and vascular dysfunction in type II diabetes, improves renal function in patients with chronic kidney disease, and reduces liver inflammation in patients with non-alcoholic fatty liver disease. The beneficial role of supplemental CoQ10 in the above disorders is considered to result from a combination of its roles in cellular energy generation, as an antioxidant and as an anti-inflammatory agent.

Keywords: coenzyme Q10; oxidative stress; inflammation; diabetes; cardiovascular disease; chronic kidney disease and liver disease; mitochondria

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