Coenzyme Q10 Supplementation in Aging and Disease

Coenzyme Q10 Supplementation in Aging and Disease

Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in all cells by a highly regulated pathway that involves a mitochondrial multiprotein complex. Defects in either the structural and/or regulatory components of CoQ complex or in non-CoQ biosynthetic mitochondrial proteins can result in a decrease in CoQ concentration and/or an increase in oxidative stress. Besides CoQ10 deficiency syndrome and aging, there are chronic diseases in which lower levels of CoQ10 are detected in tissues and organs providing the hypothesis that CoQ10 supplementation could alleviate aging symptoms and/or retard the onset of these diseases. Here, we review the current knowledge of CoQ10 biosynthesis and primary CoQ10 deficiency syndrome, and have collected published results from clinical trials based on CoQ10 supplementation. There is evidence that supplementation positively affects mitochondrial deficiency syndrome and the symptoms of aging based mainly on improvements in bioenergetics. Cardiovascular disease and inflammation are alleviated by the antioxidant effect of CoQ10. There is a need for further studies and clinical trials involving a greater number of participants undergoing longer treatments in order to assess the benefits of CoQ10 treatment in metabolic syndrome and diabetes, neurodegenerative disorders, kidney diseases, and human fertility.

Full Study


Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization 2

Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization

Objectives: Bioavailability of supplements with coenzyme Q10 (CoQ10) in humans seems to depend on the excipients of formulations and on physiological characteristics of the individuals. The aim of this study was to determine which factors presented in CoQ10 supplements affect the different response to CoQ10 in humans.

Methods: We tested seven different supplement formulations containing 100 mg of CoQ10 in 14 young, healthy individuals. Bioavailability was measured as area under the curve of plasma CoQ10 levels over 48 h after ingestion of a single dose. Measurements were repeated in the same group of 14 volunteers in a dou- ble-blind crossover design with a minimum of 4 wk washout between intakes.

Results: Bioavailability of the formulations showed large differences that were statistically significant. The two best absorbable formulations were soft-gel capsules containing ubiquinone (oxidized CoQ10) or ubiqui- nol (reduced CoQ10). The matrix used to dissolve CoQ10 and the proportion and addition of preservatives such as vitamin C affected the bioavailability of CoQ10. Although control measurements documented that all formulations contained 100 mg of either CoQ10 or ubiquinol, some of the participants showed high and others lower capacity to reach high increase of CoQ10 in blood, indicating the participation of individual unknown physiological factors.

Conclusion: This study highlights the importance of individually adapted selection of best formulations to reach the highest bioavailability of CoQ10 in humans.

Full Study


Two open job offer 2

Prof Alberto Sanz is looking to hire two postdoctoral researchers to work in his lab.  The two research projects offered are below:
For further details please contact 
Alberto Sanz, PhD
Principal Research Associate
Institute for Cell and Molecular Biosciences &
Newcastle University Institute for Ageing
Newcastle University
Campus for Ageing and Vitality
Newcastle upon Tyne
NE4 5PL
United Kingdome-mail: alberto.sanz@ncl.ac.uk
skype: albertosanzmontero
Tel:    +44191 208 1221

Journal Antioxidants Agreement with ICQA 2

International CoQ10 Association and the journal Antioxidants have agreed to promote the diffusion of the new advances of CoQ research presented in the association’s scientific meetings and workshops.

Also we agreed to facilitate the publication of the scientific results obtained by the members of the association.

Please, follow up this link


ICQA Conference 2018 FINAL Announcement 2

The 9thConference of the International Coenzyme Q10 Association

New York, NY

June 21-24, 2018

Understanding coenzyme Q10 in health and wellbeing

The  International Coenzyme Q10 Association is pleased to announce that its 9th conference is going to be held at the Faculty House, Columbia University,  West 116th Street, New York, on June 21-242018.

PROGRAMME

The scientific programme is being prepared and will soon be ready.

Deadline for abstracts is March 31st. Abstracts should not be longer than two pages, including figures and references and should be sent to: mglebocki@icqaproject.org.

DOWNLOAD DATA

For further information please contact Sharina Cabrasawan (sc3745@cumc.columbia.edu) local organizing committee, or Monica Glebocki (mglebocki@icqaproject.org) ICQA secretariat.

 

LINK: REGISTRATION PAGE

Accommodations in the surroundings:

The Empire Hotel ( https://empirehotelnyc.com )

44 west 63th street

 

NYLO New York City ( https://www.nylohotelnyc.com )

2178 Broadway

 

Hudson NY ( https://www.morganshotelgroup.com/hudson/hudson-new-york )

358 west 58th street

 

Hotel Beacon ( http://beaconhotel.com )

2130 Broadway 75th street

 

The Hotel Newton ( http://www.thehotelnewton.com/ )

2528 Broadway @ 95th Street

 

 


captura-de-pantalla-2016-12-12-a-las-11-09-30
           Seville/Madrid, 2nd November 2016. The European Medicines Agency (EMA) has designated Ubiquinol as an orphan drug for the treatment of primary coenzyme Q10 deficiency, a serious rare disease which produces muscular, nervous system and kidney disorders and can cause failures of other organs.

Download the full notice here


COMMISSION IMPLEMENTING DECISION of 14.10.2016

Relating to the designation of “Ubiquinol” as an orphan medicinal product under Regulation (EC) No 141/2000 of the European Parliament and of the Council

http://ec.europa.eu/health/documents/community-register/html/o1765.htm

Download the File